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KMID : 1161420160190020148
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Journal of Medicinal Food
2016 Volume.19 No. 2 p.148 ~ p.154
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Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK
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Chae Hee-Sung
Kim Young-Mi
Bae Jin-Kyung
Sorchhann Sochivak
Yim Sreymom
Han Ling
Paik Jin-Hyub
Choi Young-Hee
Chin Young-Won
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Abstract
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This study investigated the effects of mangosteen on metabolic syndromes in high-fat (HF) diet-fed mice and the underlying mechanisms related to adipogenesis. Mangosteen-supplemented mice gained significantly less body weight, compared with the HF group. The levels were markedly elevated in HF mice for serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, glucose, triglyceride, total cholesterol, low-density lipoprotein (LDL) cholesterol, and free fatty acid; whereas these levels were significantly lower in the 200?mg/kg of the mangosteen extract-treated group. The mangosteen extract did not modify high-density lipoprotein (HDL)-cholesterol, however, LDL-cholesterol was lower and HDL/LDL ratio was higher (9.4 vs. 3.7 in HF group). Furthermore, 200?mg/kg of mangosteen treatment activated the hepatic AMP-activated protein kinase and Sirtuin 1 in an in vivo system. Thus, the results of this study suggest that mangosteen extract exerts antiobesity effects by regulating energy metabolism and hepatic lipid homeostasis.
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KEYWORD
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AMP-activated protein kinase, antiobesity, Garcinia mangostana, Sirtuin 1
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